S and T is primarily luck based. Even if you have great heroes, the Molts at the end can easily wipe out your buildings, and there isn't much you can do.
You have every hero except for Arctica, which means that you have the means to do it.
S and T don't really require specific setups. PD, Val, Ghoulem, and then pick 3 of your best heroes. Then try over and over until you get the right spawn that doesn't kill all your buildings.
I used a standard corner base. Base doesn't matter as much as it should. It's all about the spawn locations.